Flu Drug Comparison – Which Medicine Works Best for You?

Got the flu and wondering which drug will get you back on your feet faster? You’re not alone. Every year people ask the same thing: should I take Tamiflu, Relenza, Xofluza, or just stick with pain relievers and decongestants? This guide breaks down the most common flu drugs, how they differ, and what to consider before you pick one.

Prescription Antivirals

The three big prescription antivirals are Tamiflu (oseltamivir), Relenza (zanamivir), and Xofluza (baloxavir). All three target the flu virus itself, not just the symptoms.

Tamiflu comes as a capsule or liquid. It works best when you start it within 48 hours of feeling sick. Most people take it for five days. It can cut the length of illness by about a day and may reduce complications. Common side effects are nausea and, rarely, mood changes. If you have an upset stomach, the liquid form might be easier.

Relenza is a dry‑powder inhaler. Like Tamiflu, it needs to be started early. The inhaler delivers the drug straight to the lungs, which can be handy if you can’t swallow pills. Some users report throat irritation or coughing after use. It’s not the first choice for people with asthma or chronic lung disease.

Xofluza is a newer option. It’s a single‑dose pill, so you don’t have to remember a five‑day course. It also works within 48 hours of symptoms and can lower the risk of hospitalization. Side effects are usually mild—headache or nausea. The main downside is price; Xofluza can be more expensive than Tamiflu or Relenza, and insurance coverage varies.

When choosing a prescription antiviral, ask yourself three things: Can you start treatment within two days? Do you have any condition that makes inhalers risky? And does your insurance cover the drug? Your doctor can help you pick the right one based on these factors.

OTC Options and Supportive Care

Not everyone needs a prescription antiviral. Most healthy adults recover with rest, fluids, and over‑the‑counter (OTC) meds. The most common OTC choices are:

• Acetaminophen (Tylenol) – lowers fever and eases aches.
• Ibuprofen (Advil, Motrin) – reduces fever, pain, and inflammation.
• Decongestants (pseudoephedrine, phenylephrine) – clear a stuffy nose.
• Cough suppressants (dextromethorphan) – quiet a hacking cough.

These meds don’t fight the virus, but they make you feel better while your immune system does the heavy lifting. Take them exactly as labeled and watch for interactions—especially if you’re on blood thinners or have high blood pressure.

Hydration is another underrated hero. Aim for at least eight glasses of water a day, and add broth or electrolyte drinks if you’re sweating a lot. Good sleep and a balanced diet speed up recovery, too.

When should you consider moving from OTC care to a prescription antiviral? If you’re older than 65, have a chronic condition (like asthma, diabetes, or heart disease), or notice worsening symptoms after 48 hours, call your doctor. Early antiviral treatment can prevent serious complications.

Bottom line: Prescription antivirals are most useful when started quickly and for people at higher risk. Otherwise, OTC meds, rest, and fluids usually do the trick. Talk to your healthcare provider to decide what’s best for your situation.

Feeling better soon starts with the right choice. Use this comparison to weigh effectiveness, side effects, cost, and convenience, then pick the flu drug that matches your needs.